FlyBase Allele Report: Dmel\ppk25[Δ5-22]

General Information

Symbol

Dmel\ppk25^Δ5-22

Species

D. melanogaster

Name

FlyBase ID

FBal0191281

Feature type

allele

Associated gene

Dmel\ppk25

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lin et al., 2005)

Progenitor genotype

P{SUPor-P}mim^KG05881

(Lin et al., 2005)

Caused by aberration

Df(2R)Δ5-22

Cytology

Description

Imprecise excision of P{SUPor-P}KG05881 generates a genomic deletion removing the 5' section and upstream promoter regions of CheB42a, along with some enhancer regions of ppk25.

(Lin et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior

(Lin et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Males homozygous for ppk25^Δ5-22 have a much reduced courtship index relative to controls. The typical climbing response to mechanosensory detection of gravity, stimulation of food intake by gustatory detection of sucrose is not affected in ppk25^Δ5-22 homozygous males. Introduction of ppk25^+tTg1 (with CheB42a^+tTg1) rescues the courtship behavior of ppk25^Δ5-22 homozygous males .

(Lin et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

ppk25^Δ5-22 has abnormal courtship behavior phenotype, non-suppressible by CheB42a^+tTg2

(Lin et al., 2005)

Suppressor of

Statement

Reference

ppk25^Δ5-22 is a suppressor of abnormal chemosensory behavior | male | adult stage phenotype of Scer\GAL4^Or47b.7.467, fru^UAS.MB

(Zhang et al., 2020)

ppk25^Δ5-22 is a suppressor of abnormal neurophysiology | male | adult stage phenotype of Scer\GAL4^Or47b.7.467, fru^UAS.MB

(Zhang et al., 2020)

Other

Statement

Reference

CheB42a^+tTg1, ppk25^Δ5-22, ppk25^+tTg1 has abnormal courtship behavior phenotype

(Lin et al., 2005)

CheB42a^+tTg1, ppk25^Δ5-22/ppk25^+tTg1 has abnormal courtship behavior phenotype

(Lin et al., 2005)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

ppk25^Δ5-22 is a non-enhancer of adult olfactory receptor neuron Or47b | male phenotype of Scer\GAL4^Or47b.7.467, fru^UAS.MB

(Zhang et al., 2020)

NOT Suppressor of

Statement

Reference

ppk25^Δ5-22 is a non-suppressor of adult olfactory receptor neuron Or47b | male phenotype of Scer\GAL4^Or47b.7.467, fru^UAS.MB

(Zhang et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of CheB42a^+tTg1 (with ppk25^+tTg1) rescues the courtship behavior of ppk25^Δ5-22 homozygous males. Introduction of CheB42a^+tTg2 fails to rescue the courtship behavior of ppk25^Δ5-22 homozygous males.

(Lin et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ppk25^Δ5-22 is rescued by ppk25^+tTg1

(Lin et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ppk25^Δ5-22

(Zhang et al., 2020, Ng et al., 2019)

Δ5-22

(Vijayan et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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