FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hep75
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General Information
Symbol
Dmel\hep75
Species
D. melanogaster
Name
FlyBase ID
FBal0191327
Feature type
allele
Associated gene
Dmel\hep
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        hep75 has no effect on the apoptotic response seen in eye discs containing dicentric chromosomes (generated using Scer\FLP1hs.PP-induced recombination in chromosomes containing inverted Scer\FRT sites). This effect is seen at 12-14 hours after heat shock of DcYy+.

        (Titen and Golic, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        hep75 is a suppressor of increased cell death phenotype of Scer\GAL4salm.PU, grndintra.UAS

        (Andersen et al., 2015)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        hep75/hep[+] is an enhancer of adult thorax | pharate adult stage phenotype of chm14

        (Miotto et al., 2006)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The severity of the thoracic cleft seen in chm14 pharate adults is enhanced by heterozygosity for hep75.

        (Miotto et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        hep75
        (Benhra et al., 2018, Muzzopappa et al., 2017, Boone et al., 2016, Andersen et al., 2015, Titen and Golic, 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)