FlyBase Allele Report: Dmel\Gfr[Gfr-1]

General Information

Symbol

Dmel\Gfr^Gfr-1

Species

D. melanogaster

Name

FlyBase ID

FBal0191461

Feature type

allele

Associated gene

Dmel\Gfr

Associated Insertion(s)

Carried in Construct

Also Known As

Gfr¹

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Ishikawa et al., 2005)

Progenitor genotype

Gfr^EY01553

(Ishikawa et al., 2005)

Cytology

Description

Δ2-3 activity on Gfr^EY01553 results in an approximate 0.8kb deletion of the 5' end of Gfr, including a putative initiation codon.

(Ishikawa et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of congenital disorder of glycosylation type II

CEA

(Ishikawa et al., 2005)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing | heat sensitive

(Ishikawa et al., 2005)

wing | heat sensitive (with Df(3R)Exel6147)

(Ishikawa et al., 2005)

wing | heat sensitive (with Gfr^Gfr-2)

(Ishikawa et al., 2005)

wing vein L3 | heat sensitive

(Ishikawa et al., 2005)

wing vein L4 | heat sensitive

(Ishikawa et al., 2005)

Detailed Description

Statement

Reference

Gfr¹ homozygotes, Gfr¹/Gfr² and Gfr¹/Df(3R)Exel6147 mutants exhibit a wing-notch phenotype at 18^oC but not 25^oC. Gfr¹ homozygotes exhibit a small terminal delta in veins III and IV of the adult wing at 25^oC.

(Ishikawa et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Gfr^Gfr-1 has wing | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.cIa/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing vein L3 | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.Tag:HA/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing vein L3 | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.cIa/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing vein L4 | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.Tag:HA/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing vein L4 | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.cIa/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing | heat sensitive phenotype, suppressible by Hsap\SLC35C1^UAS.Tag:HA/Scer\GAL4^Act5C.PI

(Ishikawa et al., 2005)

NOT suppressed by

Statement

Reference

Gfr^Gfr-1 has wing vein L3 | heat sensitive phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Hsap\SLC35C1^{R147C.UAS.Tag:HA}

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing vein L4 | heat sensitive phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Hsap\SLC35C1^{R147C.UAS.Tag:HA}

(Ishikawa et al., 2005)

Gfr^Gfr-1 has wing | heat sensitive phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Hsap\SLC35C1^{R147C.UAS.Tag:HA}

(Ishikawa et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The Gfr¹ mutant wing-notch phenotype phenotype is rescued through expression of Hsap\Gfr^Scer\UAS.cIa or Hsap\Gfr^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI.

The Gfr¹ mutant wing-notch phenotype is rescued through expression of Hsap\Gfr^Scer\UAS.cIa or Hsap\Gfr^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI.

(Ishikawa et al., 2005)

Complementation and Rescue Data

Not rescued by

Gfr^Gfr-1 is not rescued by Scer\GAL4^Act5C.PI/Gfr^{R125C.UAS.Tag:HA}

(Ishikawa et al., 2005)

Comments

The Gfr¹ mutant phenotype is rescued through expression of Gfr^Scer\UAS.cIa or Gfr^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI. Expression of Hsap\Gfr^{R147C.Scer\UAS}, under the control of Scer\GAL4^Act5C.PI does not suppress the wing-notch phenotype observed in Gfr¹ mutants.

(Ishikawa et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Gfr¹

(Ayukawa et al., 2012, Ishikawa et al., 2010, Ishikawa et al., 2005)

Gfr^Gfr-1

nac^Gfr-1

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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