FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ykiΔ.w
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General Information
Symbol
Dmel\ykiΔ.w
Species
D. melanogaster
Name
FlyBase ID
FBal0191484
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
TI{TI}ykiΔ.w
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Huang et al., 2005)
I-SceI
(Huang et al., 2005)
FLPase
(Huang et al., 2005)
ends-out gene targeting
(Huang et al., 2005)
Progenitor genotype
Associated Insertion(s)
TI{TI}ykiΔ.w
Cytology
Description

The entire yki gene has been replaced by a w+mW.hs marker.

(Huang et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In comparison to wild-type clones, ykiΔ.w mutant clones are almost completely eliminated from wing disc tissue.

      (Thompson and Cohen, 2006)

      ykiΔ.w null mutants are homozygous lethal and die as late embryos and early first instar larvae. Using Scer\FLP1ey.PN to selectively induce ykiΔ.w in over 90% of the eye disc cells results in eyes that are markedly reduced in size when compared to wild-type animals. ykiΔ.w-mutant clones generated at 40 hours after egg deposition are hardly observed in third instar wing discs, with rare clones recovered containing only a few cells. ykiΔ.w mutant clones generated at a similar stage are more frequently recovered in the eye discs but contain much fewer cells than the wild-type twin spots. ykiΔ.w mutant clones do not perturb early retina differentiation.

      (Huang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of thScer\UAS.cHa, under the control of Scer\GAL4tub, in ykiΔ.w mutant clones generated in the wing disc, rescues the lethality of these clones but results in clones that are smaller than those generated in wild-type controls.

      Expression of banEP3622, under the control of Scer\GAL4tub, in ykiΔ.w mutant clones generated in the wing disc rescues the lethality of these clones, resulting in clones that are larger than those generated in wild-type controls.

      (Thompson and Cohen, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ykiΔ.w is rescued by ykiαTub84B.PH

      (Huang et al., 2005)
      Comments

      Expression of ykiScer\FRT.αTub84B completely rescues ykiΔ.w animals to viable and phenotypically normal adult flies.

      (Huang et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ykiΔ.w
      Name Synonyms
      Secondary FlyBase IDs
        References (2)