FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RdlCB2
Open Close
General Information
Symbol
Dmel\RdlCB2
Species
D. melanogaster
Name
FlyBase ID
FBal0191494
Feature type
allele
Associated gene
Dmel\Rdl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Stilwell, 2011.4.18, Stilwell and Chouinard, 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: V304M.

(Stilwell, 2011.4.18)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:9,155,155..9,155,155 [-]
Nucleotide change:

G9155155A

Amino acid change:

V304M | Rdl-PA; V304M | Rdl-PC; V304M | Rdl-PD; V304M | Rdl-PE; V304M | Rdl-PF; V304M | Rdl-PG

Reported amino acid change:

V304M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Stilwell, 2011.4.18)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RdlCB2/+ males show abnormal night-time sleep - increased sleep time and fewer but longer sleep bouts.

      (Maurer et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      RdlCB2 has abnormal sleep | dominant | male phenotype, suppressible | partially by Lztr1MB12128

      (Maurer et al., 2020)
      NOT suppressed by
      Statement
      Reference

      RdlCB2 has increased sleep | dominant | male phenotype, non-suppressible by Lztr1MB12128

      (Maurer et al., 2020)
      Suppressor of
      Statement
      Reference

      Rdl[+]/RdlCB2 is a suppressor of decreased sleep | male phenotype of Lztr1MB12128

      (Maurer et al., 2020)

      Rdl[+]/RdlCB2 is a suppressor of abnormal sleep | male phenotype of Lztr1MB12128

      (Maurer et al., 2020)
      NOT Suppressor of
      Statement
      Reference

      Rdl[+]/RdlCB2 is a non-suppressor of lethal - all die before end of P-stage phenotype of Adar3.4.S.UAS, Scer\GAL4Act5C.PI

      (Li et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      RdlCB2/+ does not rescue the lethality of flies expressing Adar3.4.S.Scer\UAS under the control of Scer\GAL4Act5C.PI.

      (Li et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RdlCB2
      (Maurer et al., 2020, Li et al., 2014, Stilwell, 2011.4.18)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)