FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tshRNAi.UAS
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General Information
Symbol
Dmel\tshRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0191639
Feature type
allele
Associated gene
Dmel\tsh
Associated Insertion(s)
Carried in Construct
P{UAS-tsh.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Bessa and Casares, 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Bessa and Casares, 2005)
Mutagen
in vitro construct
(Bessa and Casares, 2005)
Progenitor genotype
Carried in construct
P{UAS-tsh.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat that corresponds to a region of tsh cDNA.

(Bessa and Casares, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tsh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies in which tsh RNAi is performed at the larval stage, by expression of tshdsRNA.Scer\UAS under the control of either Scer\GAL4ey.PH or Scer\GAL4arm.PS, show reduced eyes. This phenotype is variable, with eye loss being up to 75%. Flies containing clones induced at 28-72 hours AEL, in which tshdsRNA.Scer\UAS expression is driven by Scer\GAL4Act5C.PI, often show reduced eyes with abnormal morphology.

      (Bessa and Casares, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      G. Dietzl B. Dickson

      (Bessa and Casares, 2005)
      Comments
      Comments

      Used to study the phenotypic consequences of dsRNA interference (RNAi) of the tsh gene.

      (Bessa and Casares, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tshRNAi.UAS
      tshdsRNA.Scer\UAS
      tshdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)