FB2026_02 , released June 18, 2026
Allele: Dmel\CspEY22488
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General Information
Symbol
Dmel\CspEY22488
Species
D. melanogaster
Name
FlyBase ID
FBal0192685
Feature type
allele
Associated gene
Dmel\Csp
Associated Insertion(s)
P{EPgy2}CspEY22488
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bellen, 2006.8.3)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}CspEY22488
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CspEY22488 induces a decrease in quantal size and an increase in quantal content compared to wild type.

      (Brusich et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Csp[+]/CspEY22488, GluRIIASP16 has abnormal neurophysiology phenotype

      (Brusich et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Synaptic homeostasis is impaired in the NMJs of GluRIIASP16; CspEY22488/+ mutant larvae compared with either mutant alone. The double mutant larvae show the decreased quantal size seen in GluRIIASP16 mutants but the usual compensatory upregulation of quantal content is not seen: quantal content is not increased compared with heterozygous CspEY22488 mutants alone. As a result, evoked postsynaptic excitation is impaired.

      (Brusich et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CspEY22488
      (Brusich et al., 2015, Bellen, 2006.8.3)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)