FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dsim\Lhr2
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General Information
Symbol
Dsim\Lhr2
Species
D. simulans
Name
FlyBase ID
FBal0193418
Feature type
allele
Associated gene
Dsim\Lhr
Associated Insertion(s)
Carried in Construct
Also Known As
Lhr2
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    The 16 amino acid insertion that is present in frequencies near fixation in the Dsim\Lhr coding region is missing in this mutation. In addition, there is a complex mutation in a conserved sequence near the C terminus of the coding sequence, which includes a 12bp in-frame deletion and nonsynonymous mutations causing unique substitutions in 6 adjacent amino acids.

    (Maheshwari and Barbash, 2012)

    Dsim\Lhr2 lacks 16 amino acid residues that are normally present in Dsim\Lhr+ (it also contains other amino acid substitutions relative to Dsim\Lhr+).

    (Brideau et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Hybrid male progeny of a cross of D. melanogaster females to D. simulans Dsim\Lhr1 males have a viability of approximately 49% relative to their hybrid female siblings.

        (Maheshwari and Barbash, 2012)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Dsim\Lhr2
        Lhr2
        (Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2007, Brideau et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)