FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\par-1N1S.AEMmut.UAS.mGFP6
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General Information
Symbol
Dmel\par-1N1S.AEMmut.UAS.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0193491
Feature type
allele
Associated gene
Dmel\par-1
Associated Insertion(s)
Carried in Construct
P{UAS-par-1.N1S.AEMmut-mGFP6}
Key Links
Transgenic product class
missense_variant
(Doerflinger et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Doerflinger et al., 2006)
Mutagen
in vitro construct
(Doerflinger et al., 2006)
Progenitor genotype
par-1N1S.UASp.mGFP6
(Doerflinger et al., 2006)
Carried in construct
P{UAS-par-1.N1S.AEMmut-mGFP6}
Cytology
Description

Amino acid replacement: F?A.

(Doerflinger et al., 2006)

UAS regulatory sequences drive expression of full-length cDNA sequences from a N1S isoform of par-1 with a mutated AEM domain, tagged with mGFP6.

(Doerflinger et al., 2006)

Amino acid replacement: P?A.

(Doerflinger et al., 2006)

Amino acid replacement: R?A.

(Doerflinger et al., 2006)

Amino acid replacement: V?A.

(Doerflinger et al., 2006)

Amino acid replacement: S?A.

(Doerflinger et al., 2006)

Amino acid replacement: T?A.

(Doerflinger et al., 2006)

Amino acid replacement: H?A.

(Doerflinger et al., 2006)

Amino acid replacement: G?A.

(Doerflinger et al., 2006)

Amino acid replacement: Q?A.

(Doerflinger et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
par-1
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of par-1N1S.AEMmut.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4CY2 in the follicle cells results in abnormal apical constriction of the cells in 64% of cases at stage 9-10.

      (Claret et al., 2014)

      Expression of par-1N1S.AEMmut.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4wor.PA does not affect polarity orientation in larval neuroblasts.

      (Januschke and Gonzalez, 2010)

      The oocyte nucleus is mislocalised to the centre of the oocyte in 97% of egg chambers of females expressing par-1N1S.AEMmut.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

      (Tian and Deng, 2009)

      Expression of par-1N1S.AEMmut.Scer\UAS.T:Avic\GFP-m6 in the follicle cells, under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in a penetrant oocyte polarity phenotype, illustrated by the mispositioning of the oocyte nucelus in more than half of the egg chambers.

      (Doerflinger et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      par-1N1S.AEMmut.Scer\UAS.T:Avic\GFP-m6
      par-1N1S.AEMmut.UAS.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (6)