FB2026_02 , released June 18, 2026
Allele: Dmel\Apc2c9
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General Information
Symbol
Dmel\Apc2c9
Species
D. melanogaster
Name
FlyBase ID
FBal0193604
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(McCartney et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: G306D.

(McCartney et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,165,153..24,165,153 [+]
Nucleotide change:

G24165153A

Amino acid change:

G306D | Apc2-PA; G286D | Apc2-PB; G306D | Apc2-PC

Reported amino acid change:

G306D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(McCartney et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      8% of Apc2c9 maternally mutant syncytial embryos show movement of over 2% of cortical nuclei into the embryo interior, compared to 0-3% of wild-type embryos.

      The cuticle of an average Apc2c9 maternal/zygotic embryo shows an anterior hole, is 50-60% the length of wild-type and has 2-3 patches of denticles remaining. This cuticle phenotype is less severe when embryos are raised at 180C.

      (McCartney et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Apc2c9/Apc2g10, ApcQ8 has increased occurrence of cell division | heat sensitive phenotype

      (Lee et al., 2009)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Apc2c9/Apc2g10, ApcQ8 has adult midgut | heat sensitive phenotype

      (Lee et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Apc2g10, ApcQ8/Apc2c9 adults shifted to the non-permissive temperature show an increase in BrdU incorporation in the midgut compared to controls maintained at the permissive temperature.

      (Lee et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Apc2 alleles can be divided into three categories based on their embryonic cuticle phenotypes, from weak to moderate to strong: Apc2e90 = Apc2b5 = Apc2N175K < Apc2c9 = Apc2ΔS = Apc2d40 < Apc2g41 = Apc2f90 = Apc2g10.

      (McCartney et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      APC2c9
      (McCartney et al., 2006)
      Apc2C9
      (Lee et al., 2009)
      Apc2c9
      Name Synonyms
      Secondary FlyBase IDs
        References (2)