FB2026_02 , released June 18, 2026
Allele: Dmel\Apc2cMa
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General Information
Symbol
Dmel\Apc2cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0193607
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
P{Apc2.M}
Key Links
Transgenic product class
cDNA
(McCartney et al., 2006)
wild_type
(McCartney et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(McCartney et al., 2006)
wild_type
(McCartney et al., 2006)
Mutagen
in vitro construct
(McCartney et al., 2006)
Progenitor genotype
Carried in construct
P{Apc2.M}
Cytology
Description

688bp of genomic DNA from the mRpS24 gene to the AUG codon of the Apc2 gene is fused to the Apc2 coding region from LD18122 cDNA, which is fused to the Adh polyadenylation signal.

(McCartney et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Apc2cMa partially rescues Apc2g10

      (Webb et al., 2009)

      Apc2cMa partially rescues Apc2ΔS

      (McCartney et al., 2006)

      Apc2cMa partially rescues Apc2g10

      (McCartney et al., 2006)
      Comments

      The maternal Apc2g10 mutant embryonic phenotype of increased frequency of incomplete actin rings is only partially rescued by Apc2cMa.

      (Webb et al., 2009)

      Expression of the Apc2cMa transgene partially rescues the nuclear retention phenotype of Apc2g10 syncytial embryos - the penetrance of the phenotype falls from 35% to only 14% in rescued embryos.

      Expression of the Apc2cMa transgene partially rescues the nuclear retention phenotype of Apc2ΔS syncytial embryos - the penetrance of the phenotype falls from 58% to only 15% in rescued embryos. Embryonic lethality is fully rescued in these embryos.

      (McCartney et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Apc2cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)