FB2026_03 , released September 17, 2026
Allele: Dmel\PDZ-GEFRNAi.UAS
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General Information
Symbol
Dmel\PDZ-GEFRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0193638
Feature type
allele
Associated gene
Dmel\PDZ-GEF
Associated Insertion(s)
Carried in Construct
P{UAS-PDZ-GEF.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Huelsmann et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Huelsmann et al., 2006)
Mutagen
in vitro construct
(Huelsmann et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-PDZ-GEF.RNAi}
Cytology
Description

UASt regulatory sequences drive expression of a 485bp hairpin loop of PDZ-GEF (corresponding to 4328 to 4812 of cDNA DQ423241). The 2 PDZ-GEF strands are separated by an H intron.

(Huelsmann et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
PDZ-GEF
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In embryos, expressing Gef26dsRNA.Scer\UAS under the control of Scer\GAL4srp in macrophages, the macrophages do not populate the posterior nervous system at stage 14 and leave a gap which is not entirely closed later. The macrophages become trapped between the yolk and amnioserosa.

      (Huelsmann et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Gef26dsRNA.Scer\UAS
      PDZ-GEFRNAi.UAS
      PDZ-GEFdsRNA.Scer\UAS
      PDZ-GEFdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)