FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Khc-73RNAi.UAS
Open Close
General Information
Symbol
Dmel\Khc-73RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0193857
Feature type
allele
Associated gene
Dmel\Khc-73
Associated Insertion(s)
Carried in Construct
P{UAS-Khc-73.RNAi}
Also Known As
UAS-Khc-73 RNAi
Key Links
Transgenic product class
RNAi_reagent
(Siegrist and Doe, 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Siegrist and Doe, 2005)
Mutagen
in vitro construct
(Siegrist and Doe, 2005)
Progenitor genotype
Carried in construct
P{UAS-Khc-73.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of a 621bp hairpin from exon 9 of Khc-73. The Khc-73 inverted repeat is separated by a w intron.

(Siegrist and Doe, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Khc-73
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Khc-73dsRNA.Scer\UAS under the control of Scer\GAL4wor.PA does not affect polarity orientation in larval neuroblasts.

      (Januschke and Gonzalez, 2010)

      Overexpression of the knock-down transgene Khc-73dsRNA.Scer\UAS driven by Scer\GAL4BG380 does not significantly affect synaptic transmission at larval neuromuscular junctions.

      (Tsurudome et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of the knock-down transgene Khc-73dsRNA.Scer\UAS driven by Scer\GAL4elav.Switch.PO in motor neurons can fully suppress the increase in evoked excitatory junctional currents (EJCs) and in quantal content (QC) in homozygous Df(2R)KT40 mutant larvae.

      Strong overexpression of two copies of Khc-73dsRNA.Scer\UAS together with Dcr-2Scer\UAS.cDa driven by Scer\GAL4elav.Switch.PO leads to a reduction in QC recorded at larval neuromuscular junctions compared to wild-type.

      (Tsurudome et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transfected into embryos to study the effect of dsRNA interference (RNAi) of the Khc-73 gene on microtubule-induced formation of raps/G-iα65A/dlg1 cortical crescents in neuroblasts.

      (Siegrist and Doe, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Khc-73RNAi.UAS
      Khc-73dsRNA.Scer\UAS
      Khc-73dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)