FB2026_02 , released June 18, 2026
Allele: Dmel\dcoK38R.UAS
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General Information
Symbol
Dmel\dcoK38R.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0194124
Feature type
allele
Associated gene
Dmel\dco
Associated Insertion(s)
Carried in Construct
P{UAS(-FRT)dco.K38R}
Also Known As
UAS-dcoK38R
Key Links
Transgenic product class
missense_variant
(Strutt et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Strutt et al., 2006)
Mutagen
FLPase
(Strutt et al., 2006)
Progenitor genotype
Carried in construct
P{UAS(-FRT)dco.K38R}
Cytology
Description

The FRT cassette has been excised, juxtaposing the UAS regulatory sequences and dco coding sequences, thus allowing expression of the kinase-dead dco (carries a K38R amino acid replacement).

(Strutt et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dco
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dcoK38R.Scer\UAS in the eye, under the control of Scer\GAL4GMR.PF causes a roughening of the eye, but does not affect eye size.

      (Guan et al., 2007)

      Expression of dcoK38R.Scer\UAS in the wing, driven by Scer\GAL4ptc-559.1, results in a planar polarity phenotype in which wing hairs point toward the AP boundary.

      (Strutt et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of dcoK38R.Scer\UAS in the eye, under the control of Scer\GAL4GMR.PF enhances the WGMR.PG small eye phenotype.

      (Guan et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dcoK38R.Scer\UAS
      dcoK38R.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)