FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ork1UAS.FL.cLa
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General Information
Symbol
Dmel\Ork1UAS.FL.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lalevee
FlyBase ID
FBal0194154
Feature type
allele
Associated gene
Dmel\Ork1
Associated Insertion(s)
Carried in Construct
P{UAS-Ork1.FL}
Key Links
Transgenic product class
cDNA
(Lalevee et al., 2006)
wild_type
(Lalevee et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lalevee et al., 2006)
wild_type
(Lalevee et al., 2006)
Mutagen
in vitro construct
(Lalevee et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Ork1.FL}
Cytology
Description

UASt regulatory sequences drive expression of full-length Ork1 cDNA.

(Lalevee et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ork1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  heart conduction disease
      CEA
      (Lalevee et al., 2006)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ork1Scer\UAS.FL.cLa in the whole cardiac tube during larval stages, driven by Scer\GAL4NP1029, results in a complete arrest of heart beating and a totally dilated cardiac tube. Heart beating can be restored during electrical stimulation, indicating that cardiomyocytes remain excitable and have not been affected in their contractility. Recording action potentials from membrane cardiomyocytes of Scer\GAL4NP1029>Ork1Scer\UAS.FL.cLa larvae shows that the loss of automatic cardiac activity results from a hyperpolarization of the menbrane.

      (Lalevee et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ork1Scer\UAS.FL.cLa
      Ork1UAS.FL.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lalevee
      Secondary FlyBase IDs
        References (1)