FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Coq2JV259
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General Information
Symbol
Dmel\Coq2JV259
Species
D. melanogaster
Name
FlyBase ID
FBal0194530
Feature type
allele
Associated gene
Dmel\Coq2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Liao et al., 2006)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T569A.

(Liao et al., 2006)

Amino acid replacement: L189term.

(Liao et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,315,825..8,315,825 [-]
Nucleotide change:

T8315825A

Reported nucleotide change:

T569A

Amino acid change:

L189term | Coq2-PA

Reported amino acid change:

L189term

(Liao et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes are more susceptible to infection by either E. cloacae, L. monocytogenes or B. bassiana than wild type.

      Heterozygotes are more resistant to infection by either Flock House virus, Drosophila C virus or DNA IIV-6 virus than wild type.

      (Cheng et al., 2011)

      Flies containing homozygous eyes (induced using the eyFLP method) have a glossy-eye phenotype.

      Homozygous eye discs (induced by the eyFLP method) fail to incorporate BrdU properly, but have an essentially normal patterning of neuronal clusters emerging from the morphogenetic furrow (as assayed by elav expression).

      (Liao et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Coq2JV259 is rescued by Coq2+t3

      (Cheng et al., 2011)
      Comments

      Coq2+t3 rescues the increased sensitivity of Coq2JV259 flies to infection by either E. cloacae, L. monocytogenes or B. bassiana.

      (Cheng et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that results in a "glossy-eye" phenotype in flies containing homozygous eyes (induced using the eyFLP method).

      (Liao et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Coq2JV259
      (Cheng et al., 2011, Cheng et al., 2011)
      JV259
      (Liao et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)