FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sens1CCg
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General Information
Symbol
Dmel\sens1CCg
Species
D. melanogaster
Name
FlyBase ID
FBal0194634
Feature type
allele
Associated gene
Dmel\sens
Associated Insertion(s)
Carried in Construct
P{sens.1CCg}
Key Links
Transgenic product class
missense_variant
(Acar et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Acar et al., 2006)
Mutagen
in vitro construct
(Acar et al., 2006)
Progenitor genotype
Carried in construct
P{sens.1CCg}
Cytology
Description

2 of the cysteines in the C2H2 structure of the 1st Zn-finger (out of four) are mutated to Alanines in a 21kb 'pCaSpeR4-sens' genomic rescue construct.

(Acar et al., 2006)

Amino acid replacement: C?A.

(Acar et al., 2006)
Allele components
Component
Use(s)
Encoded product / tool
sens
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      sens1CCg partially rescues sensE2

      (Acar et al., 2006)
      Fails to rescue

      sens1CCg fails to rescue sensE2

      (Acar et al., 2006)
      Comments

      sens1CCg is able to rescue many of the external sensory organs in adult sensE2 clones, which lose almost all mechanosensory bristles.

      Expression of sens1CCg is able to partially restore the number of post-orbital bristles in sensE2 clones to approximately two-thirds of the wild-type.

      Expression of sens1CCg does not rescue the lethality of sensE2 homozygous embryos. However, a significant rescue of PNS development is observed. The rescue is however, not complete, as some of the neurons are lost. In addition, the neurons exhibit differentiation, axon guidance, and fasciculation defects.

      (Acar et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sens1CCg
      Name Synonyms
      Secondary FlyBase IDs
        References (1)