FlyBase Allele Report: Dmel\CalpA[GS9103]

General Information

Symbol

Dmel\CalpA^GS9103

Species

D. melanogaster

Name

FlyBase ID

FBal0195074

Feature type

allele

Associated gene

Dmel\CalpA

Associated Insertion(s)

P{GSV6}CalpA^GS9103

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV6}CalpA^GS9103

Cytology

Description

Insertion oriented to drive expression in the sense direction starting upstream of the coding region.

(Gregory et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,425,113..19,425,113

(Buffolo et al., 2015, Gregory et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C23

(Buffolo et al., 2015)

majority die during embryonic stage, with Scer\GAL4^Mef2.PR

(Buffolo et al., 2015)

partially lethal - majority die, with CalpA^JF03391, Scer\GAL4^Mef2.PR

(Buffolo et al., 2015)

partially lethal - majority die, with Scer\GAL4^Mef2.PR

(Buffolo et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of CalpA^GS9103 under the control of Scer\GAL4^Mef2.PR results in a lethal embryonic phenotype. This is partially suppressed by co-expression of CalpA^JF03391.

Expression of CalpA^GS9103 under the control of Scer\GAL4^C23 results in locomotion defects in third instar larvae.

(Buffolo et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CalpA^GS9103, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

CalpA^GS9103, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

201527

y¹ w^67c23; P{GSV6}CalpA^GS9103/SM1

Notes on Origin

Discoverer

Comments

FlyBase curator comment: Gregory et al., 2007, Fly 1(1): 13--22 state in their Table 1 that GS line '9123' is an insertion in/near "calpain". Correspondence with R. Saint confirms this was a typo; it should be GS line '9103' (as an insertion in/near "CalpA").

(Gregory et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CalpA^GS9103

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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