FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Or42aUAS.Tag:MYC
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General Information
Symbol
Dmel\Or42aUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0195090
Feature type
allele
Associated gene
Dmel\Or42a
Associated Insertion(s)
Carried in Construct
P{UAS-Or42a.MYC}
Key Links
Transgenic product class
genomic_DNA
(Kreher et al., 2005)
wild_type
(Kreher et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Kreher et al., 2005)
wild_type
(Kreher et al., 2005)
Mutagen
in vitro construct
(Kreher et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Or42a.MYC}
Cytology
Description

UAS regulatory sequences drive expression of a PCR product (derived from Canton-S genomic DNA) corresponding to Or42a coding sequence from the second codon to the stop codon and fused in-frame with an N-terminal Tag:MYC tag.

(Kreher et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Or42a
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Or42aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 in a Df(2L)dp-79b/Dp(2;2)dppd21 background (called Δhalo) show a large increase in electrophysiological response to either 2-ethylpyrazine or 2-methylpyrazine.

      (Montague et al., 2011)

      High concentrations of ethyl acetate elicit a strong response in flies expressing Or42aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 in a Df(2L)dp-79b/Dp(2;2)dppd21.

      (Kreher et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Transgenic flies expressing Or42aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 in a 'Δhalo' genetic background (Df(2L)dp-79b/Dp(2;2)dppd21) show spontaneous activity of olfactory receptor neurons ORN-A and B (large and small spikes) when challenged with odorants. However, the maximal response of the ab3A neuron to ethyl butyrate is much lower than that recorded from wild-type flies.

      (Syed et al., 2011)

      Expression of Or42aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 rescues the odor response defects seen in pdm3f00828 mutants.

      (Tichy et al., 2008)

      Expression of Or42aScer\UAS.T:Hsap\MYC in the 'empty neuron system' (in which Scer\GAL4Or22a.8010 is used as the driver and flies are homozygous for a synthetic deletion created by combining Df(2L)dp-79b and Dp(2;2)dppd21 on to the same chromosome) confers an odor response to the mutant ab3A neuron.

      (Kreher et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Or42aScer\UAS.T:Hsap\MYC
      Or42aUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (5)