FB2026_02 , released June 18, 2026
Allele: Dmel\Or59aUAS.Tag:MYC
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General Information
Symbol
Dmel\Or59aUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0195096
Feature type
allele
Associated gene
Dmel\Or59a
Associated Insertion(s)
Carried in Construct
P{UAS-Or59a.MYC}
Key Links
Transgenic product class
genomic_DNA
(Kreher et al., 2005)
wild_type
(Kreher et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Kreher et al., 2005)
wild_type
(Kreher et al., 2005)
Mutagen
in vitro construct
(Kreher et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Or59a.MYC}
Cytology
Description

UAS regulatory sequences drive expression of a PCR product (derived from Canton-S genomic DNA) corresponding to Or59a coding sequence from the second codon to the stop codon and fused in-frame with an N-terminal Tag:MYC tag.

(Kreher et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Or59a
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Or59aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 in a Df(2L)dp-79b/Dp(2;2)dppd21 background (called Δhalo) show a large increase in electrophysiological response to either 2-ethylpyrazine or 2-methylpyrazine.

      Flies expressing Or59aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 yield a super-sustained response to 2-acetyl-3-methylpyrazine, 2-ethyl-3,5(or 6)-dimethylpyrazine, 2-ethyl-3-methylpyrazine, 2-ethyl-3-methoxypyrazine, 2,3-diethylpyrazine, 2,3,5-trimethylpyrazine, 2,6-dimethylpyrazine, 2-methoxy-3-methylpyrazine, 2,3-dimethylpyrazine and to 2,3,5,6-trimethylpyrazine. Super-sustained responses appear to decay initially with a very rapid decrease in frequency, followed by a gradual decay occurring over minutes.

      Delivery of a 10[-4] dilution of 2-ethyl-5(6)-methylpyrazine elicits a super-sustained response in flies expressing Or59aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197 in a Df(2L)dp-79b/Dp(2;2)dppd21 background (called Δhalo).

      (Montague et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Df(2L)dp-79b, Dp(2;2)dppd21, Or59aUAS.Tag:MYC, Scer\GAL4Or22a.8010 has olfactory neuron & antennal sense organ phenotype

      (Kreher et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Or59aScer\UAS.T:Hsap\MYC in the 'empty neuron system' (in which Scer\GAL4Or22a.8010 is used as the driver and flies are homozygous for a synthetic deletion created by combining Df(2L)dp-79b and Dp(2;2)dppd21 on to the same chromosome) confers an odor response to the mutant ab3A neuron.

      (Kreher et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Or59aScer\UAS.T:Hsap\MYC
      Or59aUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)