FB2026_02 , released June 18, 2026
Allele: Dmel\dj-1βGE23381
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General Information
Symbol
Dmel\dj-1βGE23381
Species
D. melanogaster
Name
FlyBase ID
FBal0195123
Feature type
allele
Associated gene
Dmel\dj-1β
Associated Insertion(s)
P{EP}dj-1βGE23381
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Park et al., 2005)
Mutagen
P-element activity
(Park et al., 2005)
Progenitor genotype
Associated Insertion(s)
P{EP}dj-1βGE23381
Cytology
Description

The insertion site of the P-element is located 15 bp upstream of the dj-1β translation start site.

(Park et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 7
      CEA
      (Fernandez-Ayala et al., 2009, Park et al., 2005)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease 7
      is ameliorated by Cint\AOXUAS.cFa
      (Fernandez-Ayala et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared with wild-type, dj-1βGE23381 mutants show increased mitochondrial reactive oxygen species (mtROS)-production.

      Zzzz\AOXScer\UAS.cFa mutants live longer than wild-type controls.

      (Sanz et al., 2010)

      Homozygous flies show reduced climbing ability compared to controls.

      (Fernandez-Ayala et al., 2009)

      dj-1βGE23381 mutants do not display any external phenotypic defects.

      The climbing ability of dj-1βGE23381 mutants is reduced to about half of that of wild type even on the first day of eclosion, indicating that dj-1βGE23381 mutants show a premature loss of climbing ability. The declining rate over time in dj-1βGE23381 mutants and wild type are similar though.

      Paraquat-administered dj-1βGE23381 mutants show further loss of climbing response compared to dj-1βGE23381 mutants without administration, whereas wild type do not show any sensitivity to paraquat at the same drug concentration.

      (Park et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The reduced climbing ability seen in dj-1βGE23381 homozygotes is substantially rescued by Zzzz\AOXScer\UAS.cFa even in the absence of a Scer\GAL4 driver, and the rescue is enhanced by the presence of either Scer\GAL4nrv2.PS or Scer\GAL4Act5C.PI.

      (Fernandez-Ayala et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DJ-1βGE23381
      (Park et al., 2005)
      dj-1βGE23381
      (Sanz et al., 2010, Fernandez-Ayala et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)