FlyBase Allele Report: Dmel\X11L[UAS.cMa]

General Information

Symbol

Dmel\X11L^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Matsuno

FlyBase ID

FBal0195804

Feature type

allele

Associated gene

Dmel\X11L

Associated Insertion(s)

Carried in Construct

P{UAS-X11L.M}

Key Links

Transgenic product class

cDNA

(Hase et al., 2002)

wild_type

(Hase et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hase et al., 2002)

wild_type

(Hase et al., 2002)

Mutagen

in vitro construct

(Vishnu et al., 2006, Hase et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-X11L.M}

Cytology

Description

UASt regulatory sequences drive expression of a full-length X11L cDNA.

(Hase et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

X11L

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PY

(Hase et al., 2002)

visible, with Scer\GAL4^GMR.PY

(Hase et al., 2002)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PY

(Hase et al., 2002)

eye disc, with Scer\GAL4^GMR.PY

(Hase et al., 2002)

four cone-cell ommatidial precursor cluster, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

interommatidial bristle, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

ommatidial precursor cluster, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

ommatidium, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

primary pigment cell, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

rhabdomere | ectopic, with Scer\GAL4^MZ1369

(Vishnu et al., 2006)

Detailed Description

Statement

Reference

Expression of X11L^Scer\UAS.cMa in the developing optic lobe and eye disc, driven by Scer\GAL4^MZ1369, results in the formation of rough eyes. Rhabdomeres in these flies are not restricted to the distal side of the fenestrated membrane, as in wild-type flies, but are found beneath this structure, displacing the lamina.

Pupal eyes that express X11L^Scer\UAS.cMa under the control of Scer\GAL4^MZ1369 frequently display fused ommatidia, misplaced bristle complexes and reduced numbers of cone cells from four to two or even to a single cell. One or both of the primary pigment cells are sometimes missing after apparently having failed to differentiate properly.

(Vishnu et al., 2006)

Expression of X11L^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PY results in defects in eye morphology. Eye discs of these animals show an increase in cell death compared to wild type.

(Hase et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

K. Matsuno

(Vishnu et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

X11L^Scer\UAS.cMa

X11L^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Matsuno

Secondary FlyBase IDs

References (2)

Report Sections

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