FB2026_02 , released June 18, 2026
Allele: Dmel\Spt5SIE-27
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General Information
Symbol
Dmel\Spt5SIE-27
Species
D. melanogaster
Name
FlyBase ID
FBal0196106
Feature type
allele
Associated gene
Dmel\Spt5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mahoney et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q632term.

(Mahoney et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,440,336..19,440,336 [+]
Nucleotide change:

C19440336T

Amino acid change:

Q632term | Spt5-PA

Reported amino acid change:

Q632term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Mahoney et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Spt5SIE-27 has decreased body weight | adult stage | dominant phenotype, enhanceable by MycP0

      (Hofstetter et al., 2024)
      Enhancer of
      Statement
      Reference

      Spt5SIE-27 is an enhancer of visible phenotype of Psn9/Psn143

      (Mahoney et al., 2006)
      NOT Enhancer of
      Statement
      Reference

      Spt5SIE-27 is a non-enhancer of abnormal developmental rate phenotype of MycP0

      (Hofstetter et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      Spt5SIE-27 is a non-suppressor of abnormal developmental rate phenotype of MycP0

      (Hofstetter et al., 2024)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Spt5SIE-27 is an enhancer of eye phenotype of Psn9/Psn143

      (Mahoney et al., 2006)
      Other
      Statement
      Reference

      MycP0, Spt5SIE-27 has eye phenotype

      (Hofstetter et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SIE-27
      (Mahoney et al., 2006)
      Spt5SIE-27
      Spt5[SIE-27]
      (Hofstetter et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)