FlyBase Allele Report: Dmel\tsr[hs.PB]

General Information

Symbol

Dmel\tsr^hs.PB

Species

D. melanogaster

Name

heat shock promoter construct of Blair

FlyBase ID

FBal0196162

Feature type

allele

Associated gene

Dmel\tsr

Associated Insertion(s)

Carried in Construct

P{tsr.WHTG}

Key Links

Transgenic product class

genomic_DNA

(Blair et al., 2006)

wild_type

(Blair et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Blair et al., 2006)

wild_type

(Blair et al., 2006)

Mutagen

in vitro construct

(Blair et al., 2006)

Progenitor genotype

Carried in construct

P{tsr.WHTG}

Cytology

Description

A heat shock promoter drives expression of tsr. The tsr genomic fragment is 2548bp, starting 101bp upstream of the translation start site ATG and continuing to 385bp downstream of the TAA stop codon.

(Blair et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

tsr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity, with tsr^Δ96

(Blair et al., 2006)

Phenotype Manifest In

adult abdominal sensillum, with tsr^Δ96

(Blair et al., 2006)

bract, with tsr^Δ96

(Blair et al., 2006)

leg sensillum, with tsr^Δ96

(Blair et al., 2006)

ommatidium, with tsr^Δ96

(Blair et al., 2006)

wing hair, with tsr^Δ96

(Blair et al., 2006)

Detailed Description

Statement

Reference

tsr^hs.PB; tsr^Δ96 flies show extensive planar cell polarity defects. In adult wings, the hairs do not uniformly point distally as they do in wild type. In the eye, ommatidia show random chirality and polarity. In the abdomen, fine hairs and bristles frequently have non-posterior orientations. Legs display aberrant tarsal joints and joint duplications and leg bristles often show non-distal orientations. Bracts at the base of bristle show opposite directions; for example, two bracts may have correct polarity but the third may have reversed polarity.

tsr^hs.PB/Y; tsr^Δ96/+ flies appear wild type.

(Blair et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

tsr^hs.PB partially rescues tsr^Δ96

(Blair et al., 2006)

Comments

Expression of tsr^hs.PB rescues tsr^Δ96 flies following a heat shock. A small number of flies are rescued when there is no heat shock.

(Blair et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tsr^hs.PB

Name Synonyms

heat shock promoter construct of Blair

Secondary FlyBase IDs

References (1)

Report Sections

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