FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mad1.UAS
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General Information
Symbol
Dmel\Mad1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0196177
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
P{UAS-Mad.1}
Also Known As
UAS-Mad1
Key Links
Transgenic product class
missense_variant
(Takaesu et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Takaesu et al., 2005)
Mutagen
in vitro construct
(Takaesu et al., 2006)
Progenitor genotype
Mad1
(Takaesu et al., 2006)
Carried in construct
P{UAS-Mad.1}
Cytology
Description

UASt regulatory sequences drive expression of Mad coding sequence that has been mutated to reflect the Mad1 mutated sequence (carries the amino acid replacement A615T).

(Takaesu et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mad
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mad1.Scer\UAS in the wing under the control of Scer\GAL469B leads to vein truncations and incomplete wing outgrowth, including truncations to L2/L3/L4/L5 wing veins, abnormal crossveins, and a moderate margin notch.

      Approximately 52% of the expected Mad1.Scer\UAS/Scer\GAL4T80, 55% of the Mad1.Scer\UAS/Scer\GAL4Dll-md23 flies and 69% of the Mad1.Scer\UAS/Scer\GAL4how-24B flies survive, indicating significant reductions in viability.

      (Takaesu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Mad1.UAS, Scer\GAL4A9 is an enhancer of visible phenotype of Scer\GAL4A9, SnooUAS.cTa

      (Takaesu et al., 2006)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Mad1.UAS, Scer\GAL4A9 is an enhancer of wing phenotype of Scer\GAL4A9, SnooUAS.cTa

      (Takaesu et al., 2006)

      Mad1.UAS, Scer\GAL4A9 is an enhancer of wing vein phenotype of Scer\GAL4A9, SnooUAS.cTa

      (Takaesu et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Mad1.Scer\UAS significantly enhances the wing phenotypes caused by expression of SnooScer\UAS.cTa under the control of Scer\GAL4A9; the wing is very small and veinless in the co-expressing flies.

      (Takaesu et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mad1.Scer\UAS
      Mad1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)