FlyBase Allele Report: Dmel\trsn[Δ]

General Information

Symbol

Dmel\trsn^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0196831

Feature type

allele

Associated gene

Dmel\trsn

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Murakami et al., 2016)

Mutagen

P-element activity

(Claussen et al., 2006)

Progenitor genotype

trsn^EY06981

(Claussen et al., 2006)

Cytology

Description

Imprecise excision of the insertion in trsn, resulting in a deletion that extends out in both directions from the site of the original insertion and deletes the trsn coding region.

(Claussen et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep | adult stage | nutrition conditional

(Murakami et al., 2016)

abnormal starvation stress response | adult stage

(Murakami et al., 2016)

fertile

(Claussen et al., 2006)

viable

(Claussen et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Under 12:12 light:dark zeitgeber cycles, trsn^Δ homozygous mutants present increased average sleep time and decreased waking activity upon starvation conditions but not under normal diet conditions, as compared to wild-type controls; trsn^Δ homozygous mutants do not show the starvation-induced sleep deprivation and increased waking activity observed in wild-type controls.

The compensatory increase in day-time sleep induced by mechanical night-time sleep deprivation observed in wild-type controls is not affected in trsn^Δ homozygous mutant adults, as compared to controls.

Upon 24h starvation, trsn^Δ homozygous mutant adults show similar intake of and similar proboscis extension reflex to either sugar-rich (sucrose solution) or protein-rich (yeast extract) tastants, as compared to controls; trsn^Δ homozygous mutant adults also present unaltered food intake under either fed or starved conditions, as compared to controls under the same dietary conditions.

trsn^Δ homozygous mutant adults present similar glycogen, triglyceride and free glucose levels under either fed and starved states, as compared to controls.

(Murakami et al., 2016)

No differences in the rate of X chromosome nondisjunction are seen between trsn^Δ/Df(2R)stan2 females and males and control flies.

trsn^Δ/Df(2R)stan2 flies are not more sensitive to γ-irradiation than control flies.

(Claussen et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Trax^W151stop, trsn^Δ has viable phenotype

(Claussen et al., 2006)

Trax^W151stop, trsn^Δ has fertile phenotype

(Claussen et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

trsn^Δ is rescued by Scer\GAL4^Lk.PK/trsn^UAS.cMa

(Murakami et al., 2016)

trsn^Δ is rescued by Scer\GAL4^nSyb.PS/trsn^UAS.cMa

(Murakami et al., 2016)

Comments

Expression of trsn^Scer\UAS.cMa under the control of either Scer\GAL4^Lk.PK or Scer\GAL4^nSyb.PS, in an trsn^Δ homozygous mutant background, re-instates the starvation-induced sleep deprivation observed in wild-type controls.

(Murakami et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

translin^null

(Claussen et al., 2006)

trsn^null

(Murakami et al., 2016)

trsn^Δ

Δtrsn

(Claussen et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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