FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\baf1
Open Close
General Information
Symbol
Dmel\baf1
Species
D. melanogaster
Name
FlyBase ID
FBal0197138
Feature type
allele
Associated gene
Dmel\baf
Associated Insertion(s)
P{?lacW}baf1
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Furukawa et al., 2003)
Mutagen
Delta2-3 transposase
(Furukawa et al., 2003)
Progenitor genotype
P{lacW}l(2)k10210k10210
(Furukawa et al., 2003)
Associated Insertion(s)
P{?lacW}baf1
Cytology
Description

Imprecise excision of the P{lacW}l(2)k10210k10210 insertion, resulting in a deletion of approximately 1kb that removes the entire baf open reading frame. A 1074bp fragment of the P{lacW} element remains.

(Furukawa et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are not able to develop beyond the larval-pupal transition. The imaginal discs are absent in homozygous larvae and the central nervous system (CNS) is considerably smaller than normal.

      Very few mitotic cells are seen in the CNS of late third instar homozygous larvae, and the few mitotic cells that are seen have grossly abnormal chromosome morphology.

      BrdU incorporation in the CNS during late larval development is reduced in homozygotes compared to controls. Some nuclei of larval CNS cells show ultrastructural abnormalities; in some cases the uniform distribution of chromatin seen in control nuclei is lost and heterochromatin-like clumps appear, and in some cases the nuclear envelope is highly folded (particularly where clumped chromatin is most prominent). Nuclear pore complexes appear morphologically normal.

      (Furukawa et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      baf1 is rescued by baftFa

      (Furukawa et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: Ckas1883.

      (Furukawa et al., 2003)

      Complements: Cka05836.

      (Furukawa et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      baf1
      (Duan et al., 2023, Duan et al., 2020, Furukawa et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)