FB2026_02 , released June 18, 2026
Allele: Dmel\Cp190H53-2
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General Information
Symbol
Dmel\Cp190H53-2
Species
D. melanogaster
Name
FlyBase ID
FBal0197447
Feature type
allele
Associated gene
Dmel\Cp190
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pai et al., 2004)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G650A.

(Pai et al., 2004)

The mutation results in creation of a stop codon prematurely at nucleotide 650, so generating a protein of size 154 residues, prematurely truncated from 1096 residues.

(Pai et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,273,996..15,273,996 [-]
Nucleotide change:

C15273996T

Reported nucleotide change:

G11099738A

Amino acid change:

Q155term | Cp190-PA; Q155term | Cp190-PB

Reported amino acid change:

?155term

Comment:

The nucleotide change was reported relative to GenBank gi:20349357 (positive strand).

(Pai et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cp190H53-2 flies are late pupal lethal. Some escapers develop into adults that move extremely slow, cannot fly, and die soon after eclosing. Their wings extend slightly outward to about 15 degrees and very often fail to extend and/or contain fluid between the two wing layers.

      Df(3R)E(mod)4-1P11/Cp190H53-2 transheterozygotes are lethal during late pupal stages.

      (Pai et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      y2 ct6; Df(3R)E(mod)4-1P11/Cp190H53-2 flies, which are removed from the pupal cases very late in pupal development, display a black cuticle coloration in the abdomen, indicating complete suppression of y2. The shape and margins of the wings are normal, indicating complete suppression of ct6.

      (Pai et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CP190H53-2
      (Pai et al., 2004)
      Cp190H53-2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)