FB2026_02 , released June 18, 2026
Allele: Dmel\spri6G1
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General Information
Symbol
Dmel\spri6G1
Species
D. melanogaster
Name
FlyBase ID
FBal0197824
Feature type
allele
Associated gene
Dmel\spri
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jekely et al., 2005)
Progenitor genotype
P{EP}spriEP1492
(Jekely et al., 2005)
Cytology
Description

Imprecise excision of P{EP}EP1492 has deleted sequence encoding exons 1-6 of the spri b-isoform (exon 1 starts just 5' of the P{EP}EP1492 insertion site).

(Jekely et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      spri6G1 homozygous adults are resistant to acute food deprivation, as compared to controls. Larval fat body cells show decreased density of Rab5-positive vesicular structures in fed individuals, but not in starved individuals, as compared to controls.

      (Bourouis et al., 2019)

      spri6G1 mutants do not exhibit any discernible phenotype in the adult brain.

      (Rowshanravan et al., 2014)

      spri6G1 homozygous flies are viable and fertile with normal oogenesis.

      (Jekely et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      spri6G1/spri6G1 is a suppressor of abnormal starvation stress response | adult stage phenotype of vap2

      (Bourouis et al., 2019)

      spri6G1/spri6G1 is a suppressor of short lived | calorie restriction conditional phenotype of vap2

      (Bourouis et al., 2019)

      spri6G1/spri[+] is a suppressor of abnormal starvation stress response | adult stage phenotype of vap2

      (Bourouis et al., 2019)

      spri6G1/spri[+] is a suppressor of short lived | calorie restriction conditional phenotype of vap2

      (Bourouis et al., 2019)

      spri6G1/spri[+] is a suppressor of abnormal neuroanatomy phenotype of vap2

      (Rowshanravan et al., 2014)
      Other
      Statement
      Reference

      spri6G1, vap2 has abnormal starvation stress response | adult stage phenotype

      (Bourouis et al., 2019)

      spri6G1, vap2 has short lived | calorie restriction conditional phenotype

      (Bourouis et al., 2019)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      spri6G1/spri6G1 is an enhancer of border follicle cell | somatic clone phenotype of CblF165

      (Jekely et al., 2005)
      Suppressor of
      Statement
      Reference

      spri6G1 is a suppressor of adult brain phenotype of vap2

      (Rowshanravan et al., 2014)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      vap2/vap2, spri6G1/spri6G1 and vap2/+, spri6G1/spri6G1 double mutants show the same increased resistance to acute food deprivation to spri6G1/spri6G1 single mutants, instead of the hypersensitivity observed in vap2/vap2 single mutants.

      (Bourouis et al., 2019)

      A homozygous spri6G1 mutant background significantly suppresses the vap2 neurodegenerative phenotype. Weaker suppression is seen in a spri6G1 heterozygous background.

      (Rowshanravan et al., 2014)

      Migration of border follicle cells is normal in spri6G1 homozygotes, or in flies carrying EgfrScer\UAS.cBa or PvrScer\UAS.cDa with Scer\GAL4slbo.2.6, but significant defects in border cell migration, including some instances of complete failure of migration are seen in spri6G1/spri6G1 EgfrScer\UAS.cBa; Scer\GAL4slbo.2.6 flies. Weaker border cell migration defects are seen in spri6G1/spri6G1 PvrScer\UAS.cDa Scer\GAL4slbo.2.6 flies.

      spri6G1/spri6G1 also enhances the migration defects seen in border follicle cells in CblF165 homozygous somatic clones. I these animals, border follicle cell clusters rarely reach the oocyte.

      (Jekely et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spri6G1
      (Bourouis et al., 2019, Rowshanravan et al., 2014)
      sprint6G1
      (Jekely et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)