FB2026_02 , released June 18, 2026
Allele: Hsap\MTF1UASp.cBa
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General Information
Symbol
Hsap\MTF1UASp.cBa
Species
H. sapiens
Name
FlyBase ID
FBal0198058
Feature type
allele
Associated gene
Hsap\MTF1
Associated Insertion(s)
Carried in Construct
P{UASp-hMTF-1.B}
Key Links
Transgenic product class
cDNA
(Balamurugan et al., 2004)
wild_type
(Balamurugan et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Balamurugan et al., 2004)
wild_type
(Balamurugan et al., 2004)
Mutagen
in vitro construct
(Balamurugan et al., 2004)
Progenitor genotype
Carried in construct
P{UASp-hMTF-1.B}
Cytology
Description

UASp regulatory sequences drive expression of a Hsap\MTF1 cDNA.

(Balamurugan et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Hsap\MTF1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by park25
      (Saini et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The life span of park25 mutants is increased from a median of 7 days to 19 days, upon expression of Hsap\MTF1Scer\UAS.P\T.cBa under the control of Scer\GAL4Act5C.PI.

      (Saini et al., 2011)

      Expression of Hsap\MTF1Scer\UAS.P\T.cBa under the control of Scer\GAL4Act in MTF-1140-1R homozygotes partially rescues the sensitivity of MTF-1140-1R to copper depletion (caused by the copper chelator bathocuproine disulfonate), as increase survival to eclosion is seen.

      The sensitivity of MTF-1140-1R homozygotes to heavy metal ions is partially rescued by expression of Hsap\MTF1Scer\UAS.P\T.cBa under the control of Scer\GAL4Act; increased survival is seen on exposure to 1mM or 2mM Cu2+ or on exposure to 100μM or 200μM Cd2+ compared to MTF-1140-1R homozygotes.

      (Balamurugan et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MTF1Scer\UAS.P\T.cBa
      Hsap\MTF1UASp.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)