FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\5-HT1BMB05181
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General Information
Symbol
Dmel\5-HT1BMB05181
Species
D. melanogaster
Name
FlyBase ID
FBal0198375
Feature type
allele
Associated gene
Dmel\5-HT1B
Associated Insertion(s)
Mi{ET1}5-HT1BMB05181
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}5-HT1BMB05181
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        5-HT1BMB05181 adults shows the following locomotion defects in walking assays compared to controls: a significant increase in walking distance; significant decreases in the time inactive and maximum time inactive; but insignificant changes in the time spent in the center of the assay plate, number of clockwise movements, number of shifts between active/inactive state, time active and maximum time active.

        (Rohde et al., 2016)

        5-HT1BMB05181 mutants exhibit an approximate 50% reduction in short-term memory.

        5-HT1BMB05181 mutants do not exhibit a deficit in odor or shock reactivity.

        (Johnson et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        5-HT1BMB05181
        (He et al., 2020, Gasque et al., 2013, Bellen, 2007.8.20)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)