FlyBase Allele Report: Dmel\CG31917[GD10407]

General Information

Symbol

Dmel\CG31917^GD10407

Species

D. melanogaster

Name

FlyBase ID

FBal0203093

Feature type

allele

Associated gene

Dmel\CG31917

Associated Insertion(s)

Carried in Construct

P{GD10407}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD10407}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD10407

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^c564

(Kumar et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of CG31917^GD10407 under the control of Scer\GAL4^c564 has no obvious affect on the inflammatory response to Gram-positive bacterial infection, but leads to a minor ectopic inflammatory response in basal (non-infected) conditions, as compared to controls.

(Kumar et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG31917^GD10407, Scer\GAL4^Bx-MS1096, Tfb5^GD10407 has visible phenotype

(Herrera-Cruz et al., 2012)

Phenotype Manifest In

Other

Statement

Reference

CG31917^GD10407, Scer\GAL4^Bx-MS1096, Tfb5^GD10407 has wing phenotype

(Herrera-Cruz et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Adult males expressing one copy of P{GD10407} (which results in down-regulation of both CG31917 and Tfb5 expression) under the control of one copy of Scer\GAL4^Bx-MS1096 have a slightly curled wing phenotype. When two copies of P{GD10407} are expressed under the control of two copies of Scer\GAL4^Bx-MS1096 both males and females have deformed and small wings and wing blisters are seen.

Co-expression of Tfb5^{Scer\UAS.C.T:Zzzz\His6} does not rescue the wing defects seen in flies carrying two copies of P{GD10407} expressed under the control of two copies of Scer\GAL4^Bx-MS1096.

Co-expression of CG31917^{Scer\UAS.N.T:Hsap\MYC} results in significant suppression of the wing defects seen in flies carrying two copies of P{GD10407} expressed under the control of two copies of Scer\GAL4^Bx-MS1096.

Flies expressing one copy of P{GD10407} (which results in down-regulation of both CG31917 and Tfb5 expression) under the control of one copy of Scer\GAL4^Bx-MS1096 in a homozygous Tfb5^SH1279 background show a reduction in wing size.

(Herrera-Cruz et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v25909

w¹¹¹⁸; P{GD10407}v25909

v25908

w¹¹¹⁸; P{GD10407}v25908/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG31917^GD10407

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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