FlyBase Allele Report: Dmel\Usp10[GD5121]

General Information

Symbol

Dmel\Usp10^GD5121

Species

D. melanogaster

Name

FlyBase ID

FBal0203342

Feature type

allele

Associated gene

Dmel\Usp10

Associated Insertion(s)

Carried in Construct

P{GD5121}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD5121}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD5121

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^dpp.PU

(Zhang et al., 2012)

lethal, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

lethal, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^bbg-C96

(Zhang et al., 2012, Zhang et al., 2012)

Phenotype Manifest In

sarcomere, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

scutellar bristle | increased number, with Scer\GAL4^dpp.PU

(Zhang et al., 2012)

wing, with Scer\GAL4^bbg-C96

(Zhang et al., 2012, Zhang et al., 2012)

Z disc, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

Detailed Description

Statement

Reference

Expression of CG32479^GD5121 under the control of Scer\GAL4^bbg-C96 results in a notched wing phenotype.

Expression of CG32479^GD5121 under the control of Scer\GAL4^dpp.PU results in lethality at 29[o]C. At lower temperatures in some CG32479^GD5121 insertion lines, escapers with more scutellar bristles than normal are seen.

(Zhang et al., 2012)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early larval lethality or early pupal lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in sarcomeres with discontinuous Z-lines in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality before the pupal stage.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development