FlyBase Allele Report: Dmel\Lztr1[GD4339]

General Information

Symbol

Dmel\Lztr1^GD4339

Species

D. melanogaster

Name

FlyBase ID

FBal0204050

Feature type

allele

Associated gene

Dmel\Lztr1

Associated Insertion(s)

Carried in Construct

P{GD4339}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4339}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4339

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

abnormal sleep | male, with Scer\GAL4^elav-C155

(Maurer et al., 2020)

abnormal sleep | male, with Scer\GAL4^nSyb.PS

(Maurer et al., 2020)

abnormal sleep | male, with Scer\GAL4^Rdl.PS

(Maurer et al., 2020)

abnormal sleep | male | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Maurer et al., 2020)

decreased rate of movement | adult stage | male limited, with Scer\GAL4^elav-C155

(Maurer et al., 2020)

decreased sleep | male | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Maurer et al., 2020)

decreased sleep | male limited, with Scer\GAL4^elav-C155

(Maurer et al., 2020)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible | adult stage, with Scer\GAL4^Act5C.PI

(Bigenzahn et al., 2018)

Phenotype Manifest In

wing vein | ectopic, with Scer\GAL4^Act5C.PI

(Bigenzahn et al., 2018)

Detailed Description

Statement

Reference

Expression of Lztr1^GD4339 under the control of Scer\GAL4^elav-C155 leads to decreased sleep only during night-time; males also show more but shorter day-time and night-time sleep bouts and decreased night-time motion bout activity, and recover lost sleep upon sleep deprivation although less that controls.

Expression under the control of Scer\GAL4^nSyb.PS does not affect total sleep but leads to more but shorter night-time sleep bouts.

Expression under the control of Scer\GAL4^Rdl.PS leads to more but shorter night-time sleep bouts.

Adulthood-only expression under the control of Scer\GAL4^{elav.Switch.PO} (induced by RU486 treatment) leads to abnormal night-time sleep - decreased sleep time and more but shorter night-time sleep bouts.

(Maurer et al., 2020)

Expression of Lztr1^GD4339 under the control of Scer\GAL4^Act5C.PI leads to extra veins and vein tissue compared to controls.

(Bigenzahn et al., 2018)

Adults expressing CG3711^GD4339 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) can show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies, depending on the particular P{GD4339} insertion line used.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development