FlyBase Allele Report: Dmel\Ilp2[GD15756]

General Information

Symbol

Dmel\Ilp2^GD15756

Species

D. melanogaster

Name

FlyBase ID

FBal0207369

Feature type

allele

Associated gene

Dmel\Ilp2

Associated Insertion(s)

Carried in Construct

P{GD15756}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD15756}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD15756

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size, with Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Ilp2^GD15756 under the control of Scer\GAL4^nSyb.PU (in combination with UAS-Dicer2 to increase RNAi efficiency) does not result in a significant change in the latency to sperm ejection in females after the end of copulation.

(Lee et al., 2015)

Adults expressing Ilp2^GD15756 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Animals expressing Ilp2^GD15756 under the control of Scer\GAL4^Ddc.PL develop at the same rate as and do not differ in weight from control animals.

(Kaplan et al., 2008)

Expression of Ilp2^GD15756 using Scer\GAL4^Ilp2.PR reduces body size by 15%.

(Lee et al., 2008)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

15756

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Ilp2^GD15756, Scer\GAL4^Ilp2.PR has decreased body size phenotype, non-suppressible by sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Suppressor of

Statement

Reference

Ilp2^GD15756, Scer\GAL4^Ilp2.PR is a suppressor of abnormal stress response phenotype of Scer\GAL4^Ilp2.PR, bsk^K53R.UAS

(Karpac et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Ilp2^GD15756 efficiently rescues the repression of growth when shifted from 25[o]C to 29[o]C in flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR.

Co-expression of Ilp2^GD15756 rescues the increased sensitivity to paraquat of flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR.

(Karpac et al., 2009)

Co-expression of sNPF-R^Scer\UAS.cLa does not significantly affect the reduction in body size seen in Ilp2^GD15756, Scer\GAL4^Ilp2.PR animals.

(Lee et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)