FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ptp52FGD2599
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General Information
Symbol
Dmel\Ptp52FGD2599
Species
D. melanogaster
Name
FlyBase ID
FBal0208162
Feature type
allele
Associated gene
Dmel\Ptp52F
Associated Insertion(s)
Carried in Construct
P{GD2599}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD2599}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD2599
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Ptp52FGD2599 under the control of Scer\GAL4Myo31DF-NP0001 leads to the following defects in the larval midgut, as compared to controls: decreased numbers of autophagosomes, identified as fluorescent Atg8a puncta, and autolysosomes, identified as fluorescent Lysotracker puncta, in the gastric caecum cells during third instar larval stage; decrease in the levels of apoptosis in the gastric caecum cells during puparium formation; delayed histolysis of larval midgut and delayed removal of the gastric caeca during metamorphosis in a significant proportion of individuals. Similar delays in histolysis of larval midgut and in the removal of the gastric caeca during metamorphosis are also observed upon expression under the combined control of Scer\GAL4tub.PU and Gal80[ts], induced only from the second instar larval stage onwards, as compared to controls.

      (Santhanam et al., 2014)

      Adults expressing Ptp52FGD2599 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in adult/pharate lethality.

      (Schnorrer et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp52FGD2599
      Name Synonyms
      Secondary FlyBase IDs
        References (6)