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FB2026_01
,
released March 12, 2026
UASt regulatory sequences drive expression of an inverted repeat.
The expression of Tom20GD2739 under the control of Scer\GAL4Cg.PA results in early third instar larval fat bodies with reduced cell sizes and dramatic accumulation of autophagosome-like structures (Atg8a-positive), although not wrapping ubiquitinated protein aggregates, as compared to controls.
Adults expressing Tom20GD2739 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.
Adults expressing Tom20GD2739 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Expression of Tom20GD2739 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) results in viable flies or complete lethality, depending on the particular P{GD2739} insertion line used.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late larval lethality.
Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.
Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.
Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.
Expression under the control of Scer\GAL4pnr-MD237 results in loss of bristles on the notum in 0% or 40-50% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.
Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 40-50% or 70-80% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.
Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 20-30% or 40-50% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.