FlyBase Allele Report: Dmel\Cul5[GD8193]

General Information

Symbol

Dmel\Cul5^GD8193

Species

D. melanogaster

Name

FlyBase ID

FBal0209310

Feature type

allele

Associated gene

Dmel\Cul5

Associated Insertion(s)

Carried in Construct

P{GD8193}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD8193}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD8193

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Cul5^GD8193 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/Cul5^GD8193 is a non-suppressor of decreased cell number | adult stage | progressive phenotype of Uch^KO

(Lee et al., 2024)

Cul5^GD8193, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/Cul5^GD8193 is a non-suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Uch^KO

(Lee et al., 2024)

Cul5^GD8193, Scer\GAL4^GMR.PU is a non-suppressor of eye | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Adults co-expressing Hsap\ATXN3^{tr.Q27.UAS.Tag:HA} and Cul5^GD8193 under the control of Scer\GAL4^GMR.PU do not present any obvious eye defects.

(Chen et al., 2019)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v52176

w¹¹¹⁸; P{GD8193}v52176

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cul-5^GD8193

Cul5^GD8193

cul-5^GD8193

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close