FlyBase Allele Report: Dmel\da[GD4440]

General Information

Symbol

Dmel\da^GD4440

Species

D. melanogaster

Name

FlyBase ID

FBal0209325

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

Carried in Construct

P{GD4440}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4440}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4440

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental disorder of mental health

CEA

(Stessman et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

longitudinal muscle cell, with Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

longitudinal trunk visceral muscle primordium, with Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in an increase in the number of neuroblasts in the larval brain compared to controls.

(Neumüller et al., 2011)

RNAi knockdown of da via expression of da^GD4440 under the control of Scer\GAL4^d.HLH54F results in a variable reduction in the number and thickness of muscle fibers as well as their uneven distribution around the midgut.

(Ismat et al., 2010)

External Data

Linkouts

Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells

4440

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^d.HLH54F, da^GD4440 has longitudinal muscle cell phenotype, enhanceable by HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

Scer\GAL4^d.HLH54F, da^GD4440 has longitudinal trunk visceral muscle primordium phenotype, enhanceable by HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

Scer\GAL4^d.HLH54F, da^GD4440 has longitudinal intestinal visceral muscle fiber phenotype, enhanceable by HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

Enhancer of

Statement

Reference

da^GD4440, Scer\GAL4^d.HLH54F is an enhancer of longitudinal muscle cell phenotype of HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

da^GD4440, Scer\GAL4^d.HLH54F is an enhancer of longitudinal trunk visceral muscle primordium phenotype of HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

da^GD4440, Scer\GAL4^d.HLH54F is an enhancer of longitudinal intestinal visceral muscle fiber phenotype of HLH54F^KK103428, Scer\GAL4^d.HLH54F

(Ismat et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

RNAi knockdown of both HLH54F and da via expression of HLH54F^KK103428 and da^GD4440, both under the control of Scer\GAL4^d.HLH54F results in an enhancement of the longitudinal gut muscle defects found in each single mutant.

(Ismat et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v51297