FlyBase Allele Report: Dmel\Pde4[GD6399]

General Information

Symbol

Dmel\Pde4^GD6399

Species

D. melanogaster

Name

FlyBase ID

FBal0209369

Feature type

allele

Associated gene

Dmel\Pde4

Associated Insertion(s)

Carried in Construct

P{GD6399}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD6399}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD6399

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing dnc^GD6399 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6399

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dcr-2^UAS.cDa, Pde4^GD6399, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | third instar larval stage phenotype

(Yuan et al., 2011)

Phenotype Manifest In

Other

Statement

Reference

Dcr-2^UAS.cDa, Pde4^GD6399, Scer\GAL4^P2.4.Pdf has dendrite | third instar larval stage phenotype

(Yuan et al., 2011)

Dcr-2^UAS.cDa, Pde4^GD6399, Scer\GAL4^P2.4.Pdf has LNv neuron | third instar larval stage phenotype

(Yuan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Wild-type larvae display differences in their LN(v) dendrite length when exposed to constant darkness versus constant light. In contrast, co-expression of dnc^GD6399 with Dcr-2^Scer\UAS.cDa in ventral lateral neurons results in indifference of LN(v) dendrite size to light exposure.

(Yuan et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6399

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pde4^GD6399

dnc^GD6399

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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