FlyBase Allele Report: Dmel\Tgs1[CB02140]

General Information

Symbol

Dmel\Tgs1^CB02140

Species

D. melanogaster

Name

FlyBase ID

FBal0211862

Feature type

allele

Associated gene

Dmel\Tgs1

Associated Insertion(s)

P{PTT-GB}moi^CB02140

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Buszczak et al., 2007)

Progenitor genotype

Associated Insertion(s)

P{PTT-GB}moi^CB02140

Cytology

Description

Insertion within an exon.

(Buszczak et al., 2007)

Allele components

Component

Use(s)

Inserted element

Tagged with

green fluorescent protein

Tag:polyHis

epitope tag

purification tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:18,255,910..18,255,910 [+]

(Chen et al., 2022, Cheng et al., 2020, Raffa et al., 2009, Buszczak et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Buszczak et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, suppressible by Tgs1^+t4

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, suppressible by Tgs1^t4.moi-G45R

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, suppressible by Tgs1^GFP

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, suppressible by Tgs1^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has abnormal meiotic cell cycle phenotype, suppressible by Tgs1^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, suppressible by moi^t4.Tgs1-GFP

(Cheng et al., 2020)

NOT suppressed by

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype, non-suppressible by moi^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has abnormal meiotic cell cycle phenotype, non-suppressible by moi^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

Other

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has viable phenotype

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has male sterile phenotype

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has abnormal meiotic cell cycle phenotype

(Cheng et al., 2020)

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has female semi-sterile phenotype

(Cheng et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has testis phenotype, suppressible by Tgs1^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

NOT suppressed by

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has testis phenotype, non-suppressible by moi^UAS.cCa/Scer\GAL4^bam.PU

(Cheng et al., 2020)

Other

Statement

Reference

Tgs1^CB02140/Tgs1^15-11, moi^CB02140/moi^15-11 has testis phenotype

(Cheng et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: moi^CB02140.

(Raffa et al., 2009)

The P{PTT-GB}moi^CB02140 insertion maps within a dicistronic locus that encodes moi (upstream ORF) and tatl (downstream ORF), being inserted in the moi ORF. Rescue analysis indicates that the telomere fusion phenotype seen in P{PTT-GB}moi^CB02140 mutants is due to an effect on the moi ORF and not on tatl. In contrast, the lethality caused by the insertion is not rescued by a transgene containing either ORF alone, but is rescued by a transgene containing functional copies of both ORFs, indicating that the lethality is due to an effect on both ORFs.

(Raffa et al., 2009)

Comments

Enhancer trap line.

(Buszczak et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG31241^CB02140

Tgs1^CB02140

dTgs1^CB0

(Chen et al., 2022)

l(3)CB02140

(Raffa et al., 2009)

tatl^CB02140

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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