FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nup154UASp.cGa
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General Information
Symbol
Dmel\Nup154UASp.cGa
Species
D. melanogaster
Name
FlyBase ID
FBal0212138
Feature type
allele
Associated gene
Dmel\Nup154
Associated Insertion(s)
Carried in Construct
P{UASp-Nup154.G}
Key Links
Transgenic product class
cDNA
(Grimaldi et al., 2007)
wild_type
(Grimaldi et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Grimaldi et al., 2007)
wild_type
(Grimaldi et al., 2007)
Mutagen
in vitro construct
(Grimaldi et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-Nup154.G}
Cytology
Description

UASp regulatory sequences drive expression of a full length wild-type Nup154 cDNA.

(Grimaldi et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Nup154
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females expressing Nup154Scer\UAS.P\T.cGa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 do not show any evident alterations in the germline or somatic cells of the egg chambers, however eggs laid by these females are unable to sustain embryo development beyond a few mitotic cycles. Males expressing Nup154Scer\UAS.P\T.cGa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 do not show any defects in sperm function or male fertility.

      (Grimaldi et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4VP16.nanos.UTR/Nup154UASp.cGa partially rescues Nup154tlp2

      (Grimaldi et al., 2007)
      Comments

      Expression of Nup154Scer\UAS.P\T.cGa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in almost complete rescue of the ovarian aspects of the Nup154tlp2 mutant phenotype; 95-98% of egg chambers and eggs have wild-type morphology.

      (Grimaldi et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nup154Scer\UAS.P\T.cGa
      Nup154UASp.cGa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)