FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dawex11
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General Information
Symbol
Dmel\dawex11
Species
D. melanogaster
Name
FlyBase ID
FBal0212326
Feature type
allele
Associated gene
Dmel\daw
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Serpe and O'Connor, 2006)
Progenitor genotype
P{GawB}dawNP4661
(Serpe and O'Connor, 2006)
Cytology
Description

Imprecise excision of a P-element located in the first intron of the daw gene, resulting in a 1.8kb deletion of daw, which includes the start codon.

(Serpe and O'Connor, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Photoreceptor axon targeting defects are not seen in homozygous larvae.

      (Zhu et al., 2008)

      Stage 17 dawex11 embryos show very mild fasciculation defects in the CNS with thinning and breaks of the exterior (third) bundle of pioneer axon fascicles. These embryos also show various motoneuron misprojections including ISN delays, stalling and misrouting of the SNa and stalling of SNb at the 13/30 synapse accompanied by defective 12/13 innervation. dawex11 mutant third-instar larvae exhibit relatively normal innervation at the 12/13 muscle cleft.

      (Serpe and O'Connor, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Actβed80, dawex11 has abnormal neuroanatomy phenotype

      (Zhu et al., 2008)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Actβed80, dawex11 has axon & photoreceptor cell R7 phenotype

      (Zhu et al., 2008)

      Actβed80, dawex11 has axon & photoreceptor cell R8 phenotype

      (Zhu et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overall brain morphology is relatively normal in dawex11 Actβed80 double mutant larvae. However, approximately 20% of the larvae have collapsed and bundled R7 and R8 growth cones in the optic lobe (this phenotype is not seen in either single mutant).

      (Zhu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      daw11
      (Upadhyay et al., 2020)
      dawex11
      (Zhu et al., 2008, Serpe and O'Connor, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)