FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Actβed80
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General Information
Symbol
Dmel\Actβed80
Species
D. melanogaster
Name
FlyBase ID
FBal0217392
Feature type
allele
Associated gene
Dmel\Actβ
Associated Insertion(s)
Carried in Construct
Also Known As
Actβ80
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhu et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: W711term.

(Zhu et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
4:1,078,649..1,078,649 [-]
Nucleotide change:

G1078649A

Amino acid change:

W711term | Actbeta-PA

Reported amino acid change:

W711term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Actβed80 mutants do not display developmental defects in neuronal remodelling of the mushroom body γ neurons.

      (Awasaki et al., 2011)

      A large fraction of homozygotes survive to the pharate adult stage and a small proportion (less than 2%) eclose. Adult escapers can not move their wings, walk very slowly and do not establish a breeding stock.

      Optic lobes develop normally and photoreceptor axons target normally in mutant larvae.

      (Zhu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Actβed80/Actβed80 is an enhancer of abnormal neuroanatomy phenotype of dawex32

      (Zhu et al., 2008)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Actβed80/Actβed80 is an enhancer of embryonic/larval optic lobe phenotype of dawex32

      (Zhu et al., 2008)

      Actβed80/Actβed80 is an enhancer of axon & eye photoreceptor cell phenotype of dawex32

      (Zhu et al., 2008)
      Other
      Statement
      Reference

      Actβed80, dawex11 has axon & photoreceptor cell R7 phenotype

      (Zhu et al., 2008)

      Actβed80, dawex11 has axon & photoreceptor cell R8 phenotype

      (Zhu et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overall brain morphology is relatively normal in dawex11 Actβed80 double mutant larvae. However, approximately 20% of the larvae have collapsed and bundled R7 and R8 growth cones in the optic lobe (this phenotype is not seen in either single mutant).

      The penetrance of the photoreceptor axon targeting phenotype seen in dawex32 homozygous larvae is increased from 4% to 50% if they are also homozygous for Actβed80.

      (Zhu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Act80
      (Upadhyay et al., 2020)
      Actβ80
      (Upadhyay et al., 2020, Moss-Taylor et al., 2019)
      ActβED80
      (Makhijani et al., 2017)
      Actβed80
      (Song et al., 2017, Awasaki et al., 2011)
      actβ<up>ed80 12</up>
      (Awasaki et al., 2011)
      actβed80
      (Wang et al., 2019, Zhu et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)