FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Grip71GE30807
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General Information
Symbol
Dmel\Grip71GE30807
Species
D. melanogaster
Name
FlyBase ID
FBal0212698
Feature type
allele
Associated gene
Dmel\Grip71
Associated Insertion(s)
P{EP}Grip71GE30807
Carried in Construct
Also Known As
Dgp71WDGE30807
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Reschen et al., 2012)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}Grip71GE30807
    Cytology
    Description

    P{EP}Grip71GE30807 is inserted in the 5' untranslated mRNA region at position 49 from the translation initiator ATG.

    (Verollet et al., 2006)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The majority of homozygous or hemizygous Grip71GE30807 mutants reach adult stage. However, they exhibit a shorter life, morphological abnormalities, and female sterility. A fourfold increase in the mitotic index, an accumulation in prometaphase stages associated with a significant hypercondensation of chromosomes and a high incidence of disorganised or monopolar spindles are observed in L3 larval brains. Moreover, mutant neuroblasts exhibit a 12% increase in aneuploidy versus wild-type brains, suggesting that spindles without Grip71 are not full functional.

        (Verollet et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Grip163GE27087, Grip71GE30807 has lethal phenotype

        (Verollet et al., 2006)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Synthetic lethality is observed when Grip163GE27087 and Grip71GE30807 are combined in the same genotype.

        (Verollet et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Dgp71WDGE30807
        (Reschen et al., 2012, Verollet et al., 2006)
        Grip71GE30807
        Name Synonyms
        Secondary FlyBase IDs
          References (2)