FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\uspΔ148
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General Information
Symbol
Dmel\uspΔ148
Species
D. melanogaster
Name
FlyBase ID
FBal0212727
Feature type
allele
Associated gene
Dmel\usp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Wahlstrom et al., 2006)
Progenitor genotype
P{lArB}ActnWG1118
(Wahlstrom et al., 2006)
Caused by aberration
Df(1)ActnΔ148
Cytology
Description

2404bp deletion that removes the 5' region of usp, the first exon of Actn and part of CG4325.

(Chavoshi et al., 2010)

Imprecise excision of the P{lArB} element resulting in the deletion of the entire first exon of the Actn gene and the 5'-end of the usp gene.

(Wahlstrom et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:2,041,152..2,043,557 [-]
Comment:

Reported as a 2404bp deletion which spans R5 coordinates X:1935185 to X:1937590 .

(Chavoshi et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Zygotic mutant embryos die at the moult between the first and second larval instar, while mutant embryos derived from homozygous female germline clones die before hatching.

      Mutant embryos lacking both maternal and zygotic usp function show incomplete head involution and dorsal closure and have aberrant midgut morphology and bloated tracheal tubes.

      (Chavoshi et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      usp3

      (Chavoshi et al., 2010)

      usp2

      (Chavoshi et al., 2010)
      Rescued by

      uspΔ148 is rescued by usptOa

      (Chavoshi et al., 2010)

      uspΔ148 is rescued by usphs.PO

      (Chavoshi et al., 2010)

      uspΔ148 is rescued by usptOa

      (Wahlstrom et al., 2006)
      Comments

      The lethality of the Df(1)ActnΔ148 chromosome is rescued by usphs.PO, indicating that the lethality of the chromosome is due to loss of usp function.

      (Chavoshi et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      uspActΔ148
      (Chavoshi et al., 2010)
      uspΔ148
      Name Synonyms
      Secondary FlyBase IDs
        References (2)