FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\unc-104R757
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General Information
Symbol
Dmel\unc-104R757
Species
D. melanogaster
Name
FlyBase ID
FBal0213212
Feature type
allele
Associated gene
Dmel\unc-104
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dickson, 2007.12.14)
Progenitor genotype
Cytology
Description

Amino acid numbering based on GenBank sequence AAF74192.

(Berger et al., 2008)

Amino acid replacement: Q990term.

(Berger et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,757,797..16,757,797 [-]
Nucleotide change:

C16757797T

Amino acid change:

Q989term | unc-104-PB; Q989term | unc-104-PC; Q1058term | unc-104-PD; Q1003term | unc-104-PE; Q1003term | unc-104-PF; Q1003term | unc-104-PG; Q989term | unc-104-PH; Q989term | unc-104-PI

Reported amino acid change:

Q990term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Berger et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In unc-104R757/unc-104P350 embryos the axonal projections of ap-expressing neurons and the overall organization of the Fas2-immunopositive scaffold are similar to wild-type controls.

      (Stratmann et al., 2019)

      Photoreceptor axons do not project correctly in the optic lobe of unc-104R757 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

      (Berger et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      R757
      (Berger et al., 2008)
      unc-104R757
      (Stratmann et al., 2019, Dickson, 2007.12.14)
      uncR757
      (Stratmann et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)