FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\rstGD2582
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General Information
Symbol
Dmel\rstGD2582
Species
D. melanogaster
Name
FlyBase ID
FBal0215106
Feature type
allele
Associated gene
Dmel\rst
Associated Insertion(s)
Carried in Construct
P{GD2582}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dietzl et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dietzl et al., 2007)
Mutagen
in vitro construct
(Dietzl et al., 2007)
Progenitor genotype
Carried in construct
P{GD2582}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dietzl et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD2582
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Down-regulation of rst through expression of rstGD2582 in the eye under the control of Scer\GAL4GMR.PF affects the arrangement of inter-ommatidial cells, primary and cone cells in a dose-dependent fashion.

      Strong reduction of rst in the eye through expression of rstGD2582 under the control of Scer\GAL4GMR.PF (in the presence of Dcr-2Scer\UAS.cDa to increase RNAi efficiency) leads to defects in organisation of cone cells and primary cells as well as in inter-ommatidial cells. Although most inter-ommatidial cells are found in direct contact with a neighboring ommatidium.

      (Bao et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reduction of both rst and kirre expression through kirredsRNA.Scer\UAS and rstGD2582 expression under the control of Scer\GAL4GMR.PF significantly enhances the patterning defects seen in rst down-regulation: 36.6% of ommatidia are found in direct contact with another ommatidium. Inter-ommatidial cells show little evidence of sorting into a single file.

      (Bao et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rstGD2582
      Name Synonyms
      Secondary FlyBase IDs
        References (2)