FB2026_02 , released June 18, 2026
Allele: Hsap\HDAC6H216A.H611A.UAS
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General Information
Symbol
Hsap\HDAC6H216A.H611A.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0215190
Feature type
allele
Associated gene
Hsap\HDAC6
Associated Insertion(s)
Carried in Construct
P{UAS-hHDAC6.H216A.H611A}
Key Links
Transgenic product class
missense_variant
(Pandey et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Pandey et al., 2007)
Mutagen
in vitro construct
(Pandey et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-hHDAC6.H216A.H611A}
Cytology
Description

UAS sequences regulate expression of a catalytically dead form of Hsap\HDAC6 (carries amino acid replacements H216A and H611A).

(Pandey et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\HDAC6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Hsap\HDAC6H216A.H611A.UAS, Scer\GAL4GMR.PU is a non-suppressor of visible | drug conditional phenotype of Hsap\ARQ52.UAS, Scer\GAL4GMR.PU

      (Pandey et al., 2007)

      Hsap\HDAC6H216A.H611A.UAS, Scer\GAL4GMR.PU is a non-suppressor of visible | heat sensitive phenotype of ProsĪ²21.UAS, Scer\GAL4GMR.PU

      (Pandey et al., 2007)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Hsap\HDAC6H216A.H611A.UAS, Scer\GAL4GMR.PU is a non-suppressor of eye | drug conditional phenotype of Hsap\ARQ52.UAS, Scer\GAL4GMR.PU

      (Pandey et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The retinal degeneration seen in flies expressing ProsĪ²21.Scer\UAS under the control of Scer\GAL4GMR.PF at 28oC is not suppressed by co-expression of Hsap\HDAC6H216A.H611A.Scer\UAS.

      The rough eye phenotype seen in flies expressing Hsap\ARQ52.Scer\UAS under the control of Scer\GAL4GMR.PF in the presence of dihydrotestosterone (DHT) is not suppressed by co-expression Hsap\HDAC6H216A.H611A.Scer\UAS.

      (Pandey et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\HDAC6H216A.H611A.Scer\UAS
      Hsap\HDAC6H216A.H611A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)