FlyBase Allele Report: Dmel\opa[12.3]

General Information

Symbol

Dmel\opa^12.3

Species

D. melanogaster

Name

FlyBase ID

FBal0215335

Feature type

allele

Associated gene

Dmel\opa

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

In(3LR)opa^12.3

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult head | ventral | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

antenna | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

eye | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

gena | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

maxillary palp | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

vibrissal bristle | heat sensitive (with opa^tsl25)

(Lee et al., 2007)

Detailed Description

Statement

Reference

opa^tsl25/opa^12.3 flies that have been shifted to the restrictive temperature postembryonically show ventral head capsule defects as adults. The eye is round rather than oval, the sensory vibrissae on the ventral side of the eye are bunched, the maxillary palps are missing, reduced or duplicated, and gena tissue appears to be missing. Occasional antennal defects are seen.

(Lee et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa^12.3 has visible phenotype

(Lee et al., 2007)

Phenotype Manifest In

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa^12.3 has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has gena phenotype

(Lee et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

In dpp^TgR46.1/+; opa^12.3/+ flies the ventral head is disrupted, the eye is round rather than oval, the sensory vibrissae on the ventral side of the eye are bunched, the maxillary palps are missing, reduced or duplicated, and gena tissue appears to be missing.

(Lee et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

opa^M

(Lee et al., 2007)

opa^Q

(Lee et al., 2007)

opa^32.3

(Lee et al., 2007)